Author: healthadmin
We all age at different rates, and no one is immune to aging. A study by researchers at Stanford Medicine using mouse and human cells found that the main culprit is that as we age, certain types of immune cells become less able to engulf other types of immune cells. So-called tissue-resident macrophages are thought to be central regulators of age-related organ deterioration. Blocking a single receptor on these cells preserved the youth of multiple organs in mice, including the brain, heart, skeletal and cardiac muscle, liver, spleen, bone marrow, kidney, and colon. This receptor specifically binds to a hormone…
Researchers at the Icahn School of Medicine at Mount Sinai have identified immune cells that form within tumors and act as builders and regulators of powerful immune hubs that play a key role in anti-tumor immunity. This discovery could lead to new strategies to make cancer immunotherapy more effective. The findings were published online on July 16th. science (DOI:10.1126/science.ady1678) revealed that specialized immune cells called dendritic cell type 1 are essential for the construction and maintenance of structures known as tertiary lymphoid structures (TLS). These organized clusters of immune cells act as local command centers, or immune “outposts,” where the…
By analyzing individual cancer cells, researchers at the Free University of Bruxelles (ULB) discovered the transcriptional regulators that govern tumor EMT, identified key master regulators that control metastasis, and uncovered new therapeutic vulnerabilities to halt metastatic dissemination. Metastasis is the process by which cancer cells spread to other organs far from their original site and is responsible for 90% of deaths in cancer patients. To cause metastasis, cancer cells undergo epithelial-to-mesenchymal transition (EMT). This is a cellular process that allows cancer cells to detach from neighboring cells, spread into the blood, and reach distant organs. Rather than a simple on/off…
Lower doses of COVID-19 booster vaccines may provide longer-lasting immunity, reducing costs and improving access to vaccination, according to a new study. The findings could also inform vaccine doses and options during future pandemics. An international research program led by the Murdoch Children’s Research Institute (MCRI) and involving more than 2,000 participants from Australia, Indonesia and Mongolia has provided new evidence to help shape future strategies to prevent the spread of COVID-19. The $17.6 million program, funded by the Coalition for Epidemic Preparedness Innovations (CEPI), evaluated various COVID-19 booster approaches through three randomized clinical trials that followed participants for up…
A person’s genetic risk of developing cannabis addiction, even in people who have never suffered from drug abuse, is linked to structural differences in the brain during adolescence. The findings indicate that some of the brain mutations previously thought to be caused by marijuana use may stem in part from genetic biological predispositions. The study was published in the Journal of Psychopharmacology. Bipolar disorder is a severe mental health condition characterized by dramatic changes in mood, energy, and activity levels. People with this condition experience intense emotional states known as mood episodes. This may include periods of extreme elation or…
Medical experts are divided on Secretary of Defense Pete Hegseth’s announcement that U.S. military personnel will be tested for testosterone deficiency during their annual physicals. “Combatants over the age of 30 will be tested annually as part of their routine medical examination,” Hegseth said in a video posted with the caption “Chief Officer of the Department of the Army.” Selective testosterone testing will be made available to young military personnel, and if recommended, testosterone replacement therapy will be administered at the discretion of the individual. Testosterone replacement therapy has become big business in recent years. Health influencers and online clinics…
Lark Health, an artificial intelligence-powered chronic disease prevention and management platform, and Samsung on Wednesday announced a multi-year strategic partnership aimed at improving preventive care and health care for older adults, including Medicare beneficiaries. Through this partnership, seniors will be able to access one or more of Lark’s 12 chronic disease management and prevention programs through Samsung Health at no out-of-pocket cost. Medicare-eligible beneficiaries will also receive care through live clinical interventions and health tracking devices connected to their mobile phones, the companies said. Samsung has a footprint of 400 million devices, which will be combined with Lark’s AI health…
The Ugandan government has remained silent about the deadly Marburg virus outbreak it reported late last month, with the World Health Organization acknowledging on Thursday that it had repeatedly requested updates on the status of investigations into how the virus started and how far it may have spread. “We have sent several additional requests for information and are waiting to hear from them specifically about the results of the investigations that we know they are conducting,” Chikwe Ihekweazu, executive director of the Geneva-based agency’s health emergencies program, said in a new briefing. Ihekwazu said the WHO had formally submitted a…
A recent medical report details the case of a man who experienced sudden, unexplained numbness and facial pain shortly after a suspected respiratory infection. This clinical report suggests that a common virus can cause long-lasting neurological problems in the face and provides evidence that doctors should consider viral history when diagnosing sudden sensory changes. This case was published in a magazine Case reports in dentistry. Nam Nguyen, Willow Meline, and Elborz Safarzadeh contributed to this report. They are affiliated with private dental clinics in Missouri City, Richmond, and Katy, Texas. The authors recorded this unusual clinical event because isolated facial…
A major international clinical trial found that finerenone can significantly slow the decline in kidney function in non-diabetic patients with chronic kidney disease (CKD). The results of this study suggest that this drug could become an important new treatment option for many patients who previously had limited treatment options other than standard therapy. The study was led by clinical pharmacologist Hid Lambers-Herpink from the University Medical Center Groningen. New England Medical Journal. Finerenone evaluated in large-scale international trial The FIND-CKD study enrolled 1,584 adults with chronic kidney disease who were followed for an average of just over three years. All…