Author: healthadmin

When researchers screen candidate tuberculosis drugs, they often have too many options. Some look promising but later turn out to be costly dead ends. “You might get thousands of compounds from a screen, but then you’ll have to decide which compounds to work on,” said James Sacchettini, Ph.D., Texas A&M AgriLife research scientist, professor in the Texas A&M College of Agriculture and Life Sciences, Department of Chemistry and Biophysics, College of Arts and Sciences, Department of Chemistry, and Roger J. Wolf Welch Foundation Scientific Chair. His lab recently built an artificial intelligence tool that allows scientists to focus on research…

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In a promising sign of the potential of focused sound waves to improve the treatment of brain tumors, UVA Health researchers have determined that tumors called gliomas may be even more amenable to targeted drug delivery than normal brain tissue. Although the research is still in its early stages, the findings help allay concerns that brain tumors may be stubbornly resistant to cutting-edge approaches. UVA scientists are using tiny “microbubbles” activated by sound waves to open the brain’s natural protective barrier known as the “blood-brain barrier,” allowing drugs to enter exactly where they are needed. Inside a brain tumor, cancer…

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New research suggests that Mohenjodaro followed a very different path than many other early cities. As the 4,000-year-old urban center grew larger, more productive, and more successful, its society appeared to grow more egalitarian. Historians have often argued that inequality increased as small agricultural settlements developed into cities. Under this traditional model, kings, priests, and other powerful leaders came to control wealth and resources, widening the gap between rich and poor. Ancient cities became more equal A York University study of Mohenjodaro, the largest city of the Indus Valley Civilization, points to the opposite pattern. The researchers examined differences in…

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Recent research published in natural mental health The study suggests that using biological and behavioral markers may help predict how well people with depression will respond to common medications. By assessing specific brain patterns and cognitive characteristics before treatment, scientists found evidence that certain patients were much more likely to experience symptom relief from antidepressants. These findings provide the basis for creating personalized treatment plans that can reduce the time and guesswork typically required to find the right treatment for depression. Major depressive disorder affects millions of people, but finding effective treatments often requires a process of trial and error.…

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Natural compounds found in rice bran may influence the strength of intestinal contractions, according to new research from Toho University. The study, led by Dr. Keisuke Ohara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Faculty of Pharmaceutical Sciences, found that ferulic acid (FA) can inhibit intestinal smooth muscle contraction by blocking voltage-gated calcium channels. The findings could ultimately support new dietary approaches for intestinal motility disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Common compounds found in whole grains Ferulic acid is a polyphenol found in many plant-based foods, especially whole grains and rice…

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Elevated levels of a blood protein called growth differentiation factor 15 during midlife were associated with about twice the incidence of dementia over the next 20 years. This protein is released from cells during aging, inflammation, and other biological stresses. This research scientific progressprovides evidence linking this protein to future cognitive decline. Previous research has identified this protein as a potential early warning sign of dementia. But scientists weren’t sure whether it simply reflected poor health or actually contributed to damaging brain processes. To find out, researchers investigated whether blood levels of this protein predicted different forms of dementia. They…

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