Author: healthadmin

1. Background: With the increasing aging of the population, high incidence of chronic diseases, and increasing number of congenital or acquired foot deformities, lower limb dysfunction and abnormal gait problems are becoming increasingly common, posing a serious threat to public health and quality of life. Gait analysis is widely considered as a sensitive biomechanical index to assess lower extremity function, disease progression, and rehabilitation effectiveness. However, existing clinical gait assessments mainly rely on laboratory equipment such as optical motion capture systems and force platforms, which are not only expensive and spatially constrained, but also fail to reflect natural movements in…

Recently, a team led by Professor Yiming Zhang of Army Medical University Xinqiao Hospital, Fazhi Qi of Fudan University Zhongshan Hospital, and Professor Junli Zhou of Southern Medical University 10th Affiliated Hospital (Dongguan People’s Hospital) focused on the regulatory mechanism of macrophage function in radiation-induced skin damage and systematically elucidated the important role of TREM2 in maintaining macrophage survival and promoting skin repair under radiation stress. This study demonstrated that irradiation activates the ROS-NRF2-ADAM17 axis that mediates TREM2 shedding, leading to increased macrophage apoptosis and impaired repair function. In contrast, supplementation with TREM2+ macrophages significantly reduced the inflammatory response and…

As you get better at recognizing familiar faces in a crowd, spotting typos at a glance, and predicting your next move, the game-sensing neurons in your brain become more attuned to sharing information rather than acting independently. That’s the conclusion of a new study by researchers at the University of Rochester and its Del Monte Neuroscience Institute. scienceThis challenges the long-standing assumption in neuroscience that learning increases efficiency by minimizing repetitions between neural signals. The study, led by Shijiao Liu, a graduate student in the labs of faculty members Ralph Hefner and Adam Snyder in the Department of Brain and…

Three new studies from the Hospital for Special Surgery (HSS) focus on the use and benefits of osseointegration (OI) for amputee patients, and in some cases challenge common beliefs about which patients benefit. Osseointegration is a surgical procedure that allows a prosthetic limb to be attached directly to the bone of a person who has undergone an amputation, eliminating the need for a traditional socket prosthesis. The study, which looked at the safety and outcomes of both femoral-level (above-knee) and tibial-level (below-knee) OI, was presented this week at the American Academy of Orthopedic Surgeons (AAOS) 2026 Annual Meeting in New…

Few drugs have gained mainstream recognition as quickly or dramatically as glucagon-like peptide-1, a GLP-1 receptor agonist. Originally approved by the FDA to treat type 2 diabetes, it has since also transformed the treatment landscape for obesity and weight management. These drugs are clearly effective. They stimulate the release of insulin and inhibit the release of another hormone, glucagon, which helps control blood sugar levels. It also helps with weight loss by decreasing appetite and slowing gastric emptying. However, hurdles to widespread use remain, including manufacturing costs, delivery systems, and side effects, especially in low- and middle-income countries. To address…

Tumor resection in the caudate lobe (a deep and hard-to-reach part of the liver) is recognized as one of the most technically challenging operations in liver surgery due to its unique anatomical location and complex vascular relationships. Researchers at Boston University’s Chobanian and Avedisyan School of Medicine have shown that it is possible to safely remove the caudate lobe and completely remove cancer even in elderly patients using a surgical robot. The clinical example they describe in the journal Annals of Surgical Oncology combines two “guidance” tools: (1) a suspension/traction technique using the ligament of Alanthius, and (2) an indocyanine…

Entering the dating world or experiencing a breakup increases the likelihood that teens will experience suicidal thoughts and behavior. Recent research published in adolescent journal They followed Chinese students over a year to understand how forming a new romantic relationship affected their mental health. Researchers found that starting a relationship or experiencing a breakup increased the odds of suicidal behavior, highlighting the clear need for better psychological support for teens. Adolescence is a time of rapid physical and emotional changes. Teenagers are figuring out who they are and how they fit into the social world around them. This difficult transition…

A machine learning model developed by Weill Cornell Medicine researchers could give clinicians early warning of complications that may occur later in pregnancy. Preeclampsia is a sudden-onset condition associated with high blood pressure before childbirth. It affects approximately 2% to 8% of pregnancies worldwide and can have serious consequences for both parents and children. A new study published March 6 in JAMA Network Open describes a machine learning-based computer model that provides continuously updated predictions of preeclampsia risk based on electronic health record data recorded during the third trimester of pregnancy. The study was co-led by Fei Wang, Ph.D., associate…

Research uncovering the origins of pineoblastoma, a rare childhood brain tumor, also reveals dependencies across multiple brain tumor types that share similar molecular programs. Scientists at St. Jude Children’s Research Hospital, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and Uppsala University have collected and profiled the largest cohort of pineoblastoma tumors to date at single-cell resolution. They discovered a set of light-sensing-related genes that are essential for pineoblastoma formation in the developing pineal gland. Researchers subsequently extended this finding to medulloblastoma and retinoblastoma, demonstrating a common developmental condition and potential common treatment dependence that could serve as a target for…

A new generation of Alzheimer’s disease drugs, the first to be shown to alter the course of Alzheimer’s disease, typically extends patients’ lives by 10 months. These antibodies, called monoclonal antibodies, reduce the buildup of amyloid, a harmful protein, in the brain and require high-dose infusions of the drug once or twice a month. Now, to reduce the frequency of treatments and potentially increase the effectiveness of anti-amyloid therapy, researchers at Washington University School of Medicine in St. Louis have developed a new cellular immunotherapy that requires just one injection to prevent amyloid plaques from forming in mice before they…