Health tech startup Cadence has secured $100 million in a Series C funding round to expand its artificial intelligence agents for chronic disease management.
Spark Capital led the funding round, with participation from Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health. The company plans to use the new funding to advance its AI agents, grow its value-based care model, and expand across new healthcare systems.
The company will raise $100 million in a Series B round in December 2021.
Spark Capital partner and Cadence board member Will Reed said in a statement that the “most important AI companies of the next decade” will be those built for areas where “technology fundamentally changes how business works.”
“Cadence was first to do the most difficult work of demonstrating clinical results, building trust with the nation’s leading health systems, and proving the safe and effective implementation of AI in care delivery,” said Reed. “No other AI care platform in the country offers this combination of scale, peer-reviewed clinical outcomes, and economic evidence.”
The company’s clinical intelligence platform identifies risks early and supports older patients between visits through daily vital monitoring, timely medication adjustment support, and personalized lifestyle coaching. It is integrated directly into partner health systems’ medical groups, electronic medical records (EMRs), and clinical workflows. A supervised AI agent monitors patient vitals daily, supports timely medication adjustments, and enables highly personalized lifestyle coaching.
Cadence founder and CEO Chris Altcheck said in a statement that the platform was built to “solve the clinical workforce constraints at the heart of the chronic disease crisis.”
“Our AI automates care under the guidance of our medical group, close oversight in compliance with our health system’s clinical protocols, and is reimbursed through our billing infrastructure and risk contracts,” said Altcheck. “We currently treat 100,000 patients in our system with partners who are committed to changing the landscape of chronic care. This investment will build the infrastructure to care for millions of people.”
Cadence works with more than 20 health systems and treats more than 100,000 patients. Executives say the company tripled its annual recurring revenue in 2025 and saved Medicare about $2.7 million each week.
Alongside the funding, Cadence announced new partnerships with Duke Health and Texas Health Resources.
“Duke Health’s mission is to improve the health of our patients and the communities we serve. The most important moments in a patient’s health often occur at home, not in the clinic,” said Dr. Jeffrey Ferranti, senior vice president and chief digital officer at Duke Health, in a statement. “With Cadence, we can connect with patients with chronic conditions 24 hours a day and continuously monitor their health, allowing us to intervene early and keep them healthy. Together, we are reimagining care with healthier patients and a stronger, more affordable healthcare system.”
The company points to peer-reviewed studies demonstrating that its model has produced validated results. A Mayo Clinic study found that Cadence’s model reduced hospitalizations by 27% and reduced total treatment costs by $1,302 per patient per year. A study published in the Journal of the American College of Cardiology found that Cadence’s telepatient care hypertension program improved blood pressure control in hypertensive patients by 70%.
