Black women are at a disproportionate risk of developing and dying from early-onset breast cancer. New research results published online by Wiley cancera peer-reviewed journal of the American Cancer Society, reveals the genes most likely to be mutated to contribute to these increased risks.
In a study of 686 young black women diagnosed with invasive breast cancer under the age of 50 in Florida and Tennessee between 2005 and 2018, genetic testing revealed that 15.3% of women carried a gene mutation associated with breast or ovarian cancer, and most had a gene mutation associated with breast or ovarian cancer. BRCA1 and BRCA2 less genes PALB2, ATMand other genes. Family history of breast cancer was common in women with breast cancer mutations. BRCA1, BRCA2and PALB2. Triple-negative breast cancer (one of the most aggressive types of cancer) was most common in women with the following symptoms: BRCA1 mutation. Additionally, most of the women who are: BRCA1 Although the mutation was diagnosed before age 40, the age at diagnosis was more evenly distributed among women with mutations in other genes up to age 50.
The findings point to the importance of breast cancer genetic testing for young black women, who are less likely to receive breast cancer genetic testing than other races and ethnicities. Such tests could identify women who are most likely to benefit from more frequent testing and preventive measures to protect their health.
“We need to test at-risk women in all populations. Testing is essential to personalize treatment strategies and enable life-saving prevention of future cancers, and by making testing available to at-risk families, they may also benefit from this information,” said lead author Tuya Pal, M.D., Ph.D., of Vanderbilt University Medical Center.
Equitable access to genetic cancer testing allows all women, regardless of race, to benefit from precision medicine and take control of their genetic health. ”
Tuya Pal, MD, Vanderbilt University Medical Center
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Reference magazines:
Beasley, Hong Kong, others. (2026) Clinicopathological features of early-onset breast cancer in unselected young black women. cancer. DOI: 10.1002/cncr.70402. https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.70402.
