Author: healthadmin

Big drug companies are aligning with President Donald Trump’s “most-favored-nation” (MFN) drug pricing policy, but the details of the negotiated concessions and their actual impact on drug affordability in the United States remain unclear. Now, as these most-favored-nation benefits come under increasing scrutiny from patient advocates and others, and on the heels of efforts by Democratic lawmakers to push for more details in late 2025, Democratic Sen. Ron Wyden (R-Ore.), ranking member of the Senate Finance Committee, is seeking answers directly from drug companies. Sponsored by six other Senate Democrats, Wyden sent 11 letters to as many drug manufacturers as…

More than 200 metabolic enzymes, many of which are normally responsible for generating energy in mitochondria, are also found directly on top of human DNA, according to research published today. Nature Communications. This study shows that different types of cells, tissues, and even cancers have unique patterns of metabolic enzymes that are compartmentalized within the nucleus and interact with DNA. This is the first evidence that human cells have what the study authors call a “nuclear metabolic fingerprint.” More research is needed to determine whether the enzymes catalyze reactions, turn genes on or off, or simply provide structural support, but…

The University of Barcelona is strengthening its position at the forefront of European research thanks to the strategic project “VISI-ON-BRAIN: Cutting-edge human in vitro and in silico biomedical tools for brain diseases”. This is a training and research program involving 15 postdoctoral researchers focused on developing a new generation of human models to advance research into complex brain disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important aspect of this effort is that research moves away from animal models and into experimental (in vitro) and calculations (in silico) model.Professor Josep M. Canals of the UB School of…

Professor Chao Zhang’s team at Southern Medical University Pearl River Hospital has developed a novel DNA nanomachine-based drug delivery and release strategy to overcome chemotherapy resistance in small cell lung cancer (SCLC). The research team identified the PRMT1/SOX2 signaling axis as a key driver of chemoresistance in SCLC, and based on this mechanism they designed DNA nanomachines that can be temporally programmed to release drugs. By precisely targeting chemoresistant tumor cells, the nanomachines rapidly release stemness inhibitors followed by sustained release of the chemotherapeutic agent cisplatin, effectively reversing tumor stemness and significantly increasing chemotherapy sensitivity. Research background Chemotherapeutic resistance remains…

1. Background: With the increasing aging of the population, high incidence of chronic diseases, and increasing number of congenital or acquired foot deformities, lower limb dysfunction and abnormal gait problems are becoming increasingly common, posing a serious threat to public health and quality of life. Gait analysis is widely considered as a sensitive biomechanical index to assess lower extremity function, disease progression, and rehabilitation effectiveness. However, existing clinical gait assessments mainly rely on laboratory equipment such as optical motion capture systems and force platforms, which are not only expensive and spatially constrained, but also fail to reflect natural movements in…

Recently, a team led by Professor Yiming Zhang of Army Medical University Xinqiao Hospital, Fazhi Qi of Fudan University Zhongshan Hospital, and Professor Junli Zhou of Southern Medical University 10th Affiliated Hospital (Dongguan People’s Hospital) focused on the regulatory mechanism of macrophage function in radiation-induced skin damage and systematically elucidated the important role of TREM2 in maintaining macrophage survival and promoting skin repair under radiation stress. This study demonstrated that irradiation activates the ROS-NRF2-ADAM17 axis that mediates TREM2 shedding, leading to increased macrophage apoptosis and impaired repair function. In contrast, supplementation with TREM2+ macrophages significantly reduced the inflammatory response and…

As you get better at recognizing familiar faces in a crowd, spotting typos at a glance, and predicting your next move, the game-sensing neurons in your brain become more attuned to sharing information rather than acting independently. That’s the conclusion of a new study by researchers at the University of Rochester and its Del Monte Neuroscience Institute. scienceThis challenges the long-standing assumption in neuroscience that learning increases efficiency by minimizing repetitions between neural signals. The study, led by Shijiao Liu, a graduate student in the labs of faculty members Ralph Hefner and Adam Snyder in the Department of Brain and…

Three new studies from the Hospital for Special Surgery (HSS) focus on the use and benefits of osseointegration (OI) for amputee patients, and in some cases challenge common beliefs about which patients benefit. Osseointegration is a surgical procedure that allows a prosthetic limb to be attached directly to the bone of a person who has undergone an amputation, eliminating the need for a traditional socket prosthesis. The study, which looked at the safety and outcomes of both femoral-level (above-knee) and tibial-level (below-knee) OI, was presented this week at the American Academy of Orthopedic Surgeons (AAOS) 2026 Annual Meeting in New…

Few drugs have gained mainstream recognition as quickly or dramatically as glucagon-like peptide-1, a GLP-1 receptor agonist. Originally approved by the FDA to treat type 2 diabetes, it has since also transformed the treatment landscape for obesity and weight management. These drugs are clearly effective. They stimulate the release of insulin and inhibit the release of another hormone, glucagon, which helps control blood sugar levels. It also helps with weight loss by decreasing appetite and slowing gastric emptying. However, hurdles to widespread use remain, including manufacturing costs, delivery systems, and side effects, especially in low- and middle-income countries. To address…

Tumor resection in the caudate lobe (a deep and hard-to-reach part of the liver) is recognized as one of the most technically challenging operations in liver surgery due to its unique anatomical location and complex vascular relationships. Researchers at Boston University’s Chobanian and Avedisyan School of Medicine have shown that it is possible to safely remove the caudate lobe and completely remove cancer even in elderly patients using a surgical robot. The clinical example they describe in the journal Annals of Surgical Oncology combines two “guidance” tools: (1) a suspension/traction technique using the ligament of Alanthius, and (2) an indocyanine…