Author: healthadmin

An analysis of data from Israel’s National Birth Registry found that congenital malformations are more common in children diagnosed with autism spectrum disorder (ASD) than in typically developing children. The most common physical abnormalities were malformations of the circulatory and genitourinary systems. Interestingly, this study suggests clear biological sex differences. Reproductive malformations were more common in boys with ASD, whereas nongenitourinary malformations (primarily cardiovascular) were more common in girls with ASD than in typically developing girls. The paper is molecular psychiatry. Autism spectrum disorders are neurological and developmental conditions that affect how a person interacts, communicates, learns, and behaves. Symptoms…

Antibiotic resistance genes (ARGs) – segments of DNA that help bacteria survive the effects of antibiotics – can be present in newborns within hours of birth, according to research presented at ESCMID Global 2026. The study analyzed meconium samples taken from 105 infants admitted to neonatal intensive care units (NICUs) within 72 hours of birth from July 2024 to July 2025. The study was part of an interdisciplinary research project led by Professor Elias Iosifidis of Aristotle University of Thessaloniki, and included pediatric infectious disease experts, neonatologists, and molecular microbiology researchers. Meconium, the first stool a newborn passes, was traditionally…

Lipid nanoparticles (LNPs) are best known for their role in the delivery of COVID-19 mRNA vaccines that have been administered to billions of people. Now, scientists are expanding its use far beyond vaccines. Researchers are working on using these small carriers to deliver therapeutic mRNA into cells for cancer treatment, inflammatory diseases, and even CRISPR systems designed to repair harmful genetic mutations. But progress is slowed by persistent challenges. For LNPs to function in the body, they must fuse with cell membranes and release their cargo. Although this process works efficiently in laboratory experiments, it is much less effective in…

A major study presented today at ESCMID Global 2026 found that antiretroviral therapy (ART) reduces accelerated biological aging by nearly four years in people living with HIV (PWH). This discovery could change the way clinicians monitor HIV treatment and long-term health outcomes. Researchers have developed the Plasma Proteomic Aging Clock (PAC), a tool that uses patterns across hundreds of blood proteins to estimate biological age, reflecting physiological aging rather than chronological age. This model was applied to participants in the Swiss HIV Cohort Study (SHCS). PAC was trained on 941 plasma samples from PWH undergoing successful ART and subsequently evaluated…

Neurogene has hired an industry veteran to take the reins as it looks to make the leap from clinical biotechnology to commercial biopharmaceuticals with leading gene therapies. Christie Schaefer is the company’s new chief commercial officer, most recently serving as senior vice president and general manager for North America at Avidity Biosciences, which was later acquired by Novartis. She also served as Chief Commercial Officer of Marinus Pharmaceuticals and previously held several positions at Alexion Pharmaceuticals. Neurogene founder and CEO Dr. Rachel McMinn said in a statement that she joined specifically to “guide our commercial strategy and prepare for the…

Sanofi’s protein-based vaccine, Nuvaxovid, defeated Moderna’s next-generation messenger RNA shot, mNexspike, in a head-to-head trial evaluating the tolerability of two coronavirus vaccines. In a Phase 4, double-blind, real-world study of 1,000 adult participants in the United States, Nuvaxovid was shown to have statistically significantly fewer side effects across all prespecified endpoints. Symptomatic reactions with Nuvaxovid were milder and shorter-lived than with mNexspike. Additionally, less than 10% of people who received Nubaxovid experienced severe side effects that interfered with their daily life, such as fatigue, headache, and fever, compared to less than 20% of people who received mNexspike. Injection site symptoms…

Researchers at the University of Lausanne (Unil) have discovered a new biological mechanism by which vitamin B7 deficiency exposes critical vulnerabilities in tumor cells. すべての細胞は、生き残るために栄養供給の変化に適応する必要があります。 However, some cells become particularly dependent on glutamine, an amino acid that plays a major role in metabolism. Glutamine provides an essential component needed for the construction of proteins and DNA, and without it cells cannot continue to grow and divide. Cancer cells are a typical example. Many tumors exhibit what scientists call “glutamine toxicity,” meaning they are highly dependent on this nutrient.この依存性は弱点と考えられていますが、多くのがんはそれを回避する方法を見つけています。 In a study published in a journal molecular cellA team led by…

The idea that fruits and vegetables can cause cancer sounds strange. Decades of research has shown that people who eat more plants tend to live longer and healthier lives and have lower rates of heart disease, stroke, and some common cancers. Lung cancer is no exception. Many large studies have found that higher fruit and vegetable intake is associated with lower risk, especially for smokers. Against this backdrop, the new suggestion that fruits and vegetables may be contributing to lung cancer in young people is surprising. The story behind this latest wave of unrest does not emerge from a definitive…

Researchers at the University of Eastern Finland have identified new geometric markers in the ventricles that may help predict which patients with idiopathic normal pressure hydrocephalus (iNPH) will benefit from shunt surgery, according to a recent study published in 2008. Central nervous system fluids and barriers. iNPH is a likely underdiagnosed disease in older adults characterized by abnormal gait, urinary urgency and incontinence, and decline in cognitive function. Unlike most dementias, iNPH stands out because symptoms often improve or reverse with timely shunt surgery. Neuroimaging is essential for the diagnosis of iNPH. However, current diagnostic markers are limited and cannot…

Pleural fluid cytology is already used in the diagnosis of cancer, especially metastatic disease, but its sensitivity may be limited. Tumor cells are easily obscured by the overwhelming number of background blood cells, and the cluster structure may be disrupted during processing. Although immunoaffinity approaches can detect malignant tumor cells (MTCCs), they may damage cells, dissociate malignant tumor cell clusters (MTCCs), or mask surface biomarkers with bound antibodies. Existing label-free microfluidic systems also face persistent trade-offs between throughput, purity, gentle handling, and the ability to separate single cells from clusters within the same platform. Based on these challenges, detailed studies…