Author: healthadmin

Chemists have achieved what many once thought impossible by stabilizing a highly reactive molecule in water, confirming a 67-year-old theory about vitamin B1. This breakthrough not only solves a long-standing biochemical mystery, but also points toward cleaner and more efficient ways to make medicines. The discovery centers on carbenes, a type of carbon with only six valence electrons. Under normal conditions, carbon atoms are most stable when they have eight electrons. With only six carbenes, it is highly unstable and reacts almost instantly with its surroundings. It usually breaks down quickly in water. For decades, scientists have suspected that vitamin…

A seminal study by researchers at the Icahn School of Medicine at Mount Sinai and colleagues in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs). This discovery brings both closure and hope to potentially thousands of families around the world who have been searching for answers for a long time. The study was published in the April 10 issue. Online publication of natural genetics (DOI: 10.1038/s41588-025-02159-5), A previously overlooked mutation in a small, non-coding gene called . RNU2-2 Responsible for relatively common NDDs. Non-coding genes are genes that do…

Gaining weight during your life can have a big impact on your health years later. In a study of more than 600,000 people, researchers at Sweden’s Lund University looked at how weight change between the ages of 17 and 60 was associated with the risk of death from various diseases. The results show a clear pattern. Weight gain during early adulthood has the greatest impact. It has long been known that obesity increases the risk of several diseases. In this new study, researchers instead looked at how weight change during adulthood affects health. The most consistent finding is that…

Updated results from the phase III NRG GY019 trial show that letrozole monotherapy (L) is noninferior to paclitaxel/carboplatin followed by letrozole (PC/L) for progression-free survival (PFS) in patients with newly diagnosed stage II-IV low-grade serous carcinoma of the ovary or peritoneum. At the second protocol-specified interim analysis (median follow-up 27.3 months), the hazard ratio (HR) for L versus PC/L was 1.30 (95% CI, 0.90 to 1.89), exceeding the prespecified futility/noninferiority margin (HR > 1.213). As of data cutoff on January 5, 2026, 77.9% of PC/L patients and 71.9% of L patients were alive and progression-free, with overall survival rates of…

Viruses are masters at entering our cells thanks to special proteins that coat their surfaces. When scientists design vaccines, they often create versions of these viral surface proteins to study how the immune system responds. But these lab-made proteins usually lack key parts found within the virus’s membrane, so they don’t necessarily behave like real viruses. This has made it difficult to understand how antibodies actually identify and neutralize these viral targets.Now, Scripps Research scientists, in collaboration with IAVI and other research institutions, have developed a platform that allows researchers to study viral surface proteins in a more natural-looking way.…

A new discovery by researchers at Marshall University’s Joan C. Edwards School of Medicine and the Hebrew University of Jerusalem identifies a potential link between COVID-19 infection and increased risk of lung cancer, driven by underlying biological mechanisms in the lungs. This study Frontiers of immunologyaims to integrate human clinical data with mechanistic studies in animal and cell models to better understand how SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), contributes to long-term lung disease. Our findings suggest that COVID-19 not only causes acute illness, but also induces biological conditions in the lungs that may contribute to…

A decreased sense of smell may be one of the earliest warning signs of Alzheimer’s disease, appearing before significant memory loss. A new study by scientists from DZNE and Ludwig Maximilians University Munich (LMU) provides new insights into why this happens. The study points to an important role for the brain’s immune system, showing that it can mistakenly attack nerve fibers essential for odor detection. Published in nature communicationsthe study combines evidence from mice and humans, including brain tissue analysis and so-called PET scans. These findings could help improve early detection and open the door to early treatment. Researchers say…

Macrophages, much like Alice in “Alice in Wonderland,” recognize and consume tumor cells that display surface markers that say “eat me.” However, if tumor cells can successfully emit a “don’t eat me” signal, they can evade detection by macrophages. To combat this, researchers have developed drugs aimed at turning off these “don’t eat me” signals. However, these treatments are not as effective as hoped for patients with acute myeloid leukemia (AML) and other blood cancers. To better understand why, a team of researchers from Massachusetts General Brigham, Dana-Farber Cancer Institute, the Massachusetts Institute of Technology and Harvard University’s Broad Institute…

A Japanese study found that when elementary school girls participated in a drum circle with their friends, levels of the hormone oxytocin in their saliva increased. Joining a drum circle with strangers had no effect on oxytocin levels. Cortisol levels did not change after these activities. The paper was published in brain and behavior. Oxytocin and cortisol are two important hormones that play a key role in how the body responds to social situations and stress. Oxytocin is sometimes referred to as the “love hormone” because it is involved in bonding, trust, and social connection. It is released during activities…

Results from a phase 2 clinical trial designed and overseen by researchers at Massachusetts General Brigham Cancer Institute showed that the investigational drug mezagitamab may effectively increase platelet counts in patients with immune thrombocytopenia (ITP). ITP is an autoimmune disease characterized by increased platelet destruction and decreased platelet production, increasing bleeding risk and impairing quality of life. The result is New England Medical Journalis particularly relevant given that approximately 20% of ITP patients do not benefit from current treatments. “This is a novel treatment that is fast-acting and attacks the underlying mechanisms of the disease,” said lead author David J.…