Author: healthadmin

Repeated menstrual cycles don’t just cause endometriosis. They may rewire the brain. This is an important finding from a new Washington State University study showing that repeated bouts of disease-related inflammation can sensitize the nervous system and cause persistent pain. This study helps explain one of the most troubling aspects of endometriosis, in which tissue similar to the endometrium grows outside the uterus. It affects more than 10% of women of reproductive age, or approximately 190 million people worldwide, and often causes severe pelvic pain and infertility. In a paper published in clinical research journalWSU scientist Kanako Hayashi and her…

A new systematic review published in brain, behavior, immunity This suggests that cannabinoid use does not have a single direct effect on the human immune system. Rather, regular use tends to increase both pro-inflammatory and anti-inflammatory biological markers simultaneously. These findings provide evidence that cannabis products may modulate the immune system and require more detailed nuances to be fully understood. Cannabis use is increasing worldwide due to changes in legal policy and public perception of its safety. At the same time, medicine views cannabis through a different lens. Certain ingredients are being studied as treatments for pain and epilepsy, but…

UCLA researchers have identified a rogue immune cell population that silently accumulates in aging tissues and in the livers of patients with fatty liver disease. They found that removing these cells dramatically reduced inflammation and reversed liver damage in the mice, even if the mice continued to eat an unhealthy diet. This research natural agingfocuses on a process called cellular senescence, a stress response in which cells stop dividing but refuse to die. Rather than quietly disappearing, these so-called “zombie cells” remain in tissues and send out a toxic cocktail of inflammatory signals. “Senescent cells are pretty rare, but think…

Researchers at University College Dublin have discovered a previously unknown ‘transmission system’ that cells use to communicate coherent biological messages to each other, opening new possibilities for medicine and biotechnology. These delivery systems also have “keys” to natural (endogenous) gateways, allowing them to reach biological locations currently inaccessible to traditional delivery medicine. “Having access to these natural gateways could enable the delivery of functional biomolecular ‘toolkits’, such as extended modifying messages, directly to previously inaccessible areas within cells and across biological barriers, potentially greatly increasing the efficacy and, importantly, safety of RNA, gene and protein-based therapies,” said lead author Associate…

Eli Lilly is wasting no time pursuing the next indication for its newly named obesity drug Foundayo, releasing new data on diabetes on Thursday that could also satisfy the FDA’s request for more safety information on oral GLP-1. The results seen with Foundayo, also known as orforglipron, enabled Lilly’s late-stage Achieve-4 study to meet its primary endpoint. Specifically, the drug demonstrated non-inferiority to insulin glargine in adults with type 2 diabetes and obesity or overweight who are at high cardiovascular risk. Professor Lilly said in a press release on April 16 that the risk of major cardiovascular events (MACE), such…

A new large-scale study led by researchers at Cedars-Sinai University of Health Sciences is raising questions about the long-term safety of some drugs commonly used to treat irritable bowel syndrome (IBS). The findings suggest that certain drugs, including antidepressants, may be associated with a small but measurable increased risk of death. Published in communication medicineThe study analyzed nearly 20 years of electronic health records of more than 650,000 U.S. adults diagnosed with IBS. This made this the largest real-world study to date focused on how safe these treatments are over the long term. Understand IBS and its treatments IBS is…

Research has shed important new light on the ability of bacteria to exchange genes from friend to foe, including genes associated with antimicrobial resistance (AMR). As researchers at the John Innes Center investigate the strange phenomenon of gene transfer agents (GTAs), they have provided insights that expand our understanding of AMR, a major global health threat. These gene-carrying particles look like bacteriophages (viruses that infect bacteria), but they were domesticated from ancient viruses and put to beneficial use under the control of bacterial host cells. They act as couriers, receiving packets of host bacteria’s DNA and delivering it to neighboring…

Health technology company Seqster on Thursday announced the launch of its new 1-Click Sites platform with BioIVT as its first deployment partner. This tool allows clinical sites to share electronic health record (EHR) data with patient consent with clinical trial sponsors. Each site or network using this platform receives its own FDA 21 CFR Part 11 compliant research portal where Seqster manages data aggregation, automated eligibility screening, and ongoing monitoring. Organizational locations can use the platform as a complete research hub or strategic referral center, according to the announcement. Seqster CEO and co-founder Ardy Arianpour said in an interview with…

Until now, keratinocytes (skin cells) were thought to be just passive conductors that allow the rabies virus to pass through, but new research reveals that these cells play a more active role. Results of new research in Journal of Research Dermatology (method), a paper published by Elsevier provides direct evidence that keratinocytes support viral replication and can transmit rabies virus to neurons. Researchers provide a mechanistic explanation for how exposure of superficial skin through scratches and minor bites by dogs and bats can cause neural invasion and contribute to infection risk. Rabies is a deadly zoonotic disease caused by rabies…

Drugs that target the amyloid beta protein in the brain increase the risk of bleeding and swelling in the brain and are likely to have no clinically meaningful positive effects, a new Cochrane review has found. Alzheimer’s patients have high concentrations of a protein known as amyloid beta in their brains and can be detected before symptoms begin, but the role of amyloid beta in the progression of the disease is unknown. Drugs have been developed on the theory that removing these proteins from the brain can prevent or slow disease progression. The new review examined data from 17 clinical…