The Biostatistics Unit of the German Institut Trias i Puyol (IGTP), in collaboration with researchers from several Catalan medical and research institutions, has developed the DIVINE research database. scientific data, nature portfolio journal. This journal is dedicated to publishing datasets, promoting the accessibility, proper documentation, and reusability of these resources by the scientific community.
The cohort includes clinical information from 5,813 patients admitted with COVID-19 infection in five hospitals in the southern metropolitan area of Barcelona during four waves of the pandemic from March 2020 to August 2021. The database includes information collected during hospitalization and follow-up, including clinical characteristics, risk factors, treatments received, and hospital outcomes.
Data is published as an R package on CRAN with associated GitHub repositories and Zenodo records for easy access, traceability, and reuse. The dataset is anonymized and can be used to study the progress of patients hospitalized with COVID-19, identify factors associated with clinical outcomes, and test predictive models. It is also useful as a teaching material in fields such as biostatistics and epidemiology.
This cohort has already contributed to several studies on in-hospital mortality, long-term sequelae, patient stratification, and the development of predictive models. With this publication, the authors make their dataset available to the scientific community to facilitate reuse in future studies and contribute to more open, reproducible, and efficient research.
Christian Thebe, Head of IGTP’s Biostatistics Unit, emphasizes: “Making clinical research data openly available is not only an act of transparency, but also an ethical commitment to science and society. It allows data to be reused, analyzes to be replicated, knowledge to be expanded, and research to be accelerated while avoiding unnecessary duplication of research.”.
The DIVINE cohort is the result of a collaborative effort involving clinicians, researchers and biostatisticians from several Catalan medical and academic institutions. The project began during the first wave of the pandemic with the establishment of a data collection system by biostatisticians from the Department of Infectious Diseases at Belvidge University Hospital and the Belvidge Institute for Biomedical Research (IDIBELL), and was subsequently expanded with the participation of additional institutions. Researchers from IGTP, Belvidge University Hospital, Polytechnic University of Catalunya, University of Barcelona, Consorsi Sanitari Integral, Consorci Sanitari Alto Penedes Garraf, Viladecans Hospital, Parc Sanitary Sant Joan de Déu Central Catalunya Institute for Research and Innovation in Life and Health Sciences, and Infectious Diseases CIBER participated in this study, as well as the MetroSud and DIVINE groups.
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German Trias i Pujol Institute
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DOI: 10.1038/s41597-026-07479-7
