The Patient-Centered Outcomes Research Institute (PCORI) today announced new funding to support patient-centered comparative clinical effectiveness research (CER) across the wide range of health conditions experienced by Americans and projects to help bring practice-changing CER results to real-world clinical settings.
Across the United States, people make decisions about their health care without always having clear information about the potential benefits and risks of different treatment options. These awards are part of PCORI’s growing portfolio of funded research that supports projects that generate information that helps patients, caregivers, and the broader medical community choose care options and help integrate evidence into everyday care.
Understanding the trade-offs between different approaches to care helps patients and their caregivers make decisions in daily clinical practice. These newly funded, patient-centered, comparative clinical effectiveness research projects will generate evidence that will help people across the United States understand their options and make better-informed choices that reflect their needs and preferences. ”
Nakela L. Cook, MD, MPH, PCORI Executive Director
Funding Highlights
- 13 new patient-centered CER studies addressing a variety of health challenges
- Four studies advance patient-centered CER approaches, including strategies for meaningful engagement of patients and those who care for them
- 15 PCORI-funded projects supporting the implementation of CER findings into real-world clinical practice
new research award
The newly awarded patient-centered CER project compares different approaches to care across a wide range of health concerns. The study will investigate:
- Initial treatment options for people with painful diabetic neuropathy.
- Efficacy and safety of anti-nausea drugs during pregnancy.
- Advanced care planning interventions in primary care settings.
- Strategies to promote sleep and reduce delirium in intensive care settings.
- Approach to dementia care support.
- Smoking cessation in community mental health care settings.
- Interventions for adults and children with chronic kidney disease.
Two additional awards were funded to CERs focused on youth trauma. One study will compare strategies to increase adoption of evidence-based treatments for trauma and substance use. The other compares approaches to treating trauma with other mental health problems.
Two additional awards will consider approaches to improve care for children with autism and children and adults with cerebral palsy.
Four additional awards will fund research designed to strengthen the implementation of patient-centered CER. These include three focused on advancing CER methodologies and one focused on building an evidence base for effective engagement of patients and other healthcare decision makers through patient-centered CER design and implementation.
Accelerate uptake of PCORI-funded research results
To ensure that results generated by PCORI-funded CERs are accessible and usable by health decision makers, PCORI funds implementation projects that accelerate the introduction of high-priority evidence into real-world clinical settings. Through the Health Systems Implementation Initiative (HSII), PCORI announced 15 new funding for projects focused on:
- Improve the diagnosis and management of hypertension.
- Electronic monitoring of patient-reported outcomes during cancer treatment.
- Expanding access to mental health care through telepsychiatry collaborative care.
These new awards have enabled HSII participant health systems to conduct implementation projects across 34 states and the District of Columbia. Collectively, these projects have the potential to impact care for more than 2 million patients across approximately 5,100 health care facilities.
sauce:
Patient-Centered Outcomes Institute

